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INVOLUTION OF MOUSE MAMMARY GLANDS DURING WHOLE ORGAN CULTURE OCCURS VIA APOPTOSIS OF EPITHELIAL TISSUE
Author(s) -
CASEY T. M.,
CHEN H.,
PLAUT K.,
CHIU J. F.
Publication year - 1996
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1996.0098
Subject(s) - involution (esoterism) , organ culture , apoptosis , mammary gland , in vivo , biology , hormone , dna fragmentation , epithelium , programmed cell death , medicine , endocrinology , in vitro , pathology , breast cancer , cancer , consciousness , biochemistry , genetics , microbiology and biotechnology , neuroscience
Apoptosis was measured in mammary glands during whole organ culture, to determine whether regression resulting from hormone withdrawal results in epithelial cell death as in vivo involution. Glands were evaluated for morphology and DNA degradation prior to whole organ culture, after lobulo‐alveolar development and 2, 4, or 6 days after hormone withdrawal. The data indicated that mammary regression during whole organ culture mimics in vivo involution and results in part from apoptosis of epithelial tissue.