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IMPLICATION OF INVOLVEMENT OF RAT CHROMOSOME #2 IN SPONTANEOUS TRANSFORMATION OF THE RAT‐2 CELL LINE
Author(s) -
KRISHNAVENI L.,
GHOSH S. N.
Publication year - 1996
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1996.0036
Subject(s) - transformation (genetics) , line (geometry) , chromosome , chemistry , microbiology and biotechnology , genetics , biology , mathematics , gene , geometry
Using an in vitro model for cell transformation, the relationship between specific chromosomal aberration and phenotypic changes was studied at different passages of Rat‐2 cell line. A marker chromosome resulting from a translocation [ t (2;7)] was found to be associated with focus formation in soft agar. Conversely, the loss of this marker chromosome was found to be associated with phenotypic reversion. These results suggest an association of this marker chromosome with phenotypic transformation for the Rat‐cell line.