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ONTOGENY OF ANGIOTENSIN II RECEPTORS
Author(s) -
SHANMUGAM SADOUTOUNNISSA,
SANDBERG KATHRYN
Publication year - 1996
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1996.0021
Subject(s) - receptor , angiotensin ii , biology , homeostasis , endocrinology , g protein coupled receptor , medicine , hormone , microbiology and biotechnology , angiotensin receptor , renin–angiotensin system , blood pressure , biochemistry
Aside from the well known role of angiotensin II (Ang II) in blood pressure regulation and fluid homeostasis, accumulating evidence suggests that the octapeptide hormone also plays a role in growth and development. There are two major classes of Ang II receptors (AT 1 and AT 2 ) which mediate Ang II action. Both classes are members of the large superfamily of seven transmembrane domain spanning receptors. Fetal tissue express high levels of AT receptors. Throughout fetal and postpartum life, the AT 1 and AT 2 tissue distribution changes dramatically. The evolution of each receptor type is distinct and varies according to the organ. Thus, the different patterns of temporal expression of each receptor class could be related to various roles that Ang II may play during development.