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TRANSCRIPTIONAL CONTROL OF CELL CYCLE PROGRESSION: THE HISTONE GENE IS A PARADIGM FOR THE G1/S PHASE AND PROLIFERATION/DIFFERENTIATION TRANSITIONS
Author(s) -
STEIN GARY S.,
STEIN JANET L.,
WIJNEN ANDRÉ J.,
LIAN JANE B.
Publication year - 1996
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1996.0007
Subject(s) - biology , microbiology and biotechnology , histone , histone h2a , chromatin , histone code , nucleosome , cell cycle , genetics , gene
The histone gene is a paradigm for transcriptional control at the G1/S phase transition point in the cell cycle. The histone gene promoter provides a blueprint for integration of regulatory signals which mediate responsiveness to factors controlling competency for cell cycle progression at the initiation of DNA replication. The downregulation of proliferation at the onset of differentiation is accompanied by and functionally linked to modifications in protein—DNA and protein—protein interactions at histone gene promoter regulatory elements. Chromatin structure, nucleosome organization and gene‐nuclear matrix interactions facilitate crosstalk between regulatory sequences and targeting of transcription factors to cognate binding domains.