Premium
Leucocyte involvement in lectin‐induced deciduomata formation
Author(s) -
Shaw Timothy J.,
Murphy Christopher R.
Publication year - 1995
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1995.1104
Subject(s) - concanavalin a , biology , infiltration (hvac) , stroma , lectin , stromal cell , epithelium , uterine horns , pathology , anatomy , immunology , uterus , endocrinology , immunohistochemistry , cancer research , medicine , biochemistry , physics , genetics , in vitro , thermodynamics
Intra‐uterine injection of the lectin Concanavalin A (ConA) on day 5 of PSP induced a rapid and persistent infiltration of leucocytes into the rat uterine stroma. Although the infiltration of leucocytes was witnessed along the entire length of the uterine horn, areas of stromal oedema, indicative of decidualisation (as indicated by the positive Pontamine Sky Blue reaction), were only associated with regions in which the movement of leucocytes across the uterine epithelium was evident. Epithelial disruption and trauma was frequently noted within these regions. We believe that ConA may initiate decidualisation through indirectly causing epithelial trauma.