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Regulation of fibronectin expression by PDGF‐BB And IGF‐I in cultured rat thoracic aortic adventitial fibroblasts.
Author(s) -
Zhang Jing,
Lo Chushek
Publication year - 1995
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1995.1096
Subject(s) - platelet derived growth factor receptor , fibronectin , platelet derived growth factor , growth factor , fibroblast , endocrinology , medicine , messenger rna , angiogenesis , biology , chemistry , cell culture , microbiology and biotechnology , receptor , biochemistry , extracellular matrix , gene , genetics
Regulation of fibronectin (FN) by Platelet‐derived Growth Factor‐BB (PDGF‐BB) and Insulin‐like Growth Factor‐I (IGF‐I) in cultured rat thoracic aortic adventitial fibroblasts were examined. PDGF‐BB enhances FN mRNA levels in a time and concentration‐dependent fashion. The effect of IGF‐I on PDGF‐BB‐induced FN levels was also examined. There was a larger increase in FN mRNA levels (4‐fold) in the cells treated with both IGF‐I and PDGF‐BB than with either IGF‐I (2‐fold) or PDGF‐BB (2‐fold) alone. The effects of PDGF‐BB and IGF‐I on FN levels were examined. There was a larger increase in FN levels (135%) in the cells treated with both PDGF‐BB and IGF‐I than with either PDGF‐BB (43%) or IGF‐I (45%) alone. Regulation of adventitial fibroblast FN may lead to blood vessel diseases and/or angiogenesis.