The effect of cisplatin and transplatin on the conformation and association of F‐actin.

The effects of cisplatin and transplatin on the conformation and association of F‐actin were studied by ESR, turbidimetry and CD measurement. The results indicate that the major component affecting F‐actin secondary conformation is derived from their effect on the tertiary or quaternary conformation and association states of F‐actin. The effect of platinum is seen by the fact that binding of cisplatin causes first an increase in molecular size followed by a later decrease. The induction time for the association depended on the concentration of cisplatin. Transplatin was able to reach the target site more readily, resulting in the dissociation of F‐actin even at a very low concentration.