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Fibroblast growth factors: at the heart of angiogenesis.
Author(s) -
Slavin J.
Publication year - 1995
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1995.1087
Subject(s) - angiogenesis , fibroblast growth factor , microbiology and biotechnology , fibroblast , cancer research , biology , computational biology , chemistry , medicine , genetics , in vitro , receptor
Acidic fibroblast growth factor (FGF‐1) and basic fibroblast growth factor (FGF‐2) are ubiquitous cytokines found in many tissues. They have effects on multiple cell types derived from mesoderm and neuroectoderm, including endothelial cells. In this review the structure and function of the fibroblast growth factor family and its receptors are described. The evidence implicating both FGF‐1 and FGF‐2 in the control of blood vessel formation is presented and their involvement in normal and pathological angiogenesis during adult life is then described in more detail.