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Oxidative stress and the development of diabetic complications ‐ antioxidants and lipid peroxidation in erythrocytes and cell membrane.
Author(s) -
Parthiban Anusha,
Vijayalingam Selvamani,
Shanmugasundaram K. Radha,
Mohan Rema
Publication year - 1995
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1995.1040
Subject(s) - lipid peroxidation , oxidative stress , antioxidant , erythrocyte membrane , diabetes mellitus , red blood cell , cell , medicine , chemistry , biochemistry , endocrinology , cell membrane , membrane , biology
Erythrocytes isolated from 131 cases of Non‐Insulin Dependent Diabetes Mellitus (NIDDM) were studied for lipid peroxidation, antioxidant defences, and the maximum peroxidisable substrate in the cell membrane. Antioxidant defences are lowered in NIDDM, followed by significant rise in lipid peroxidation products. However, in the erythrocyte membrane, the total polyunsaturated peroxidisable lipids are lower than in normal erythrocytes which may be a causative factor affecting the survival of the cells.