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Retinoic acid induces changes in Xenopus embryo glycolipid pattern
Author(s) -
Rizzo Angela M.,
Gornati Rosalba,
Rossi Federica,
Bernardini Giovanni,
Berra Bruno
Publication year - 1995
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1995.1027
Subject(s) - xenopus , glycolipid , retinoic acid , embryo , chemistry , microbiology and biotechnology , biochemistry , biology , gene
Retinoic acid (RA), known for its important role in cellular differentiation, may cause a modification of glycolipid distribution characterized by a shift from globoserie towards latto‐ and ganglio‐series. In the present paper, we have investigated the modifications of the lipidic pattern after exogenous RA treatment of Xenopus embryos. We have noticed a decrease in neutral glycolipids with a parallel increase in gangliosides; the content of sulfatides does not seem to be modified. Beside the shift toward ganglio‐serie, we have also observed a redistribution inside this class of lipids. In particular, following RA treatment, the relative distribution of GD1b and GT1b increases while that of GM3 decreases.