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The control of Ca 2+ homeostasis: role of intracellular rapidly exchanging Ca2+ stores.
Author(s) -
Villa Antonello,
Meldolesi Jacopo
Publication year - 1994
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1994.1078
Subject(s) - homeostasis , intracellular , chemistry , microbiology and biotechnology , biophysics , biochemistry , biology
The role of rapidly exchanging intracellular Ca 2+ stores in the control of Ca 2+ homeostasis is reviewed. The following issues are discussed: the reasons why such stores exist in eukaryotic cells; the differences between the terminal cisternae of the skeletal muscle sarcoplasmic reticulum, which have direct, physical connection with the T tubules of the plasmalemma, and the Ca 2+ stores located in the depth of the cytoplasm, which are stimulated by second messengers; the cytological nature (subcompartments of the ER) of the rapidly exchanging Ca 2+ stores and their functional significance. The conclusions introduce recent developments in which intracellular Ca 2+ stores have been investigated also by molecular biology techniques.