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Chemotactic response of unicellular tetrahymena to a leukocyte attractant peptide and its repellent derivate: evolutionary conclusions.
Author(s) -
Kõhidai László,
Kovács Péter,
Csaba György
Publication year - 1994
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1994.1051
Subject(s) - norleucine , tetrahymena pyriformis , chemotaxis , phenylalanine , homology (biology) , tetrahymena , leucine , character (mathematics) , biology , stereochemistry , receptor , chemistry , biochemistry , botany , amino acid , geometry , mathematics
Chemotactic properties of the leukocyte chemoattractant N‐formyl‐Norleucine‐Leucine‐Phenylalanine (NLP) and its antagonist N‐t‐BOC‐Norleucine‐Leucine‐Phenylalanine (BOC‐NLP) were investigated in unicellular Tetrahymena pyriformis cells. NLP express its attractant character in a two‐peak profile of concentration course (maximum at 10 −8 ‐10 −7 M and 10 −11 M) while BOC‐NLP has a constant repellent character (maximum at 10 −12 M). The observed homology of action concurs with our theory about the wide evolutionary background of signal molecules and receptors.