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Increased secretion of latent elastase activity following contact between human skin fibroblasts and elastin derived peptides.
Author(s) -
Landeau JeanMarie,
Pellat Bernard,
Hornebeck William
Publication year - 1994
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1994.1050
Subject(s) - elastin , elastase , secretion , pancreatic elastase , chemistry , microbiology and biotechnology , biology , biochemistry , enzyme , genetics
Elastin‐derived peptides were previously shown to influence human skin fibroblasts (HSF) chemotaxis and proliferation (Ghuysen et al., 1992). We report here that culturing HSF on κ‐elastin (κE) but not onto fibronectin (FN) enhanced the secretion of latent elastinolytic activity. The proteinase involved was identified as the 72 kDa gelatinase A. Moreover, HSF‐κE as well as HSF‐FN interactions modulated the secretions of Il 1 induced expressions of elastinolytic activities.