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Effect of pentoxifylline, a multidrug resistance reversal agent, on haemopoietic stem cell homing.
Author(s) -
Gude R. P.,
Chitnis M. P.,
Rao S. G. A.
Publication year - 1994
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1994.1045
Subject(s) - homing (biology) , stem cell , microbiology and biotechnology , pentoxifylline , cytoskeleton , biology , cell , pharmacology , biochemistry , ecology
This paper investigates the mechanism of mouse haemopoietic stem cell homing into the cytoskeleton depolymerising agent Pentoxifylline was used, and shown to inhibit stem cell homing. The inhibition was reversible after 6 hours. The results obtained suggest that the haemopoietic stem cell homing receptor is anchored to cytoskeletal support intracellularly.