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Insulin rescues the unicellular eukaryote Tetrahymena from dying in a complete, synthetic nutrient medium
Author(s) -
Christensen Søren T.
Publication year - 1993
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1993.1145
Subject(s) - tetrahymena pyriformis , tetrahymena , eukaryote , ciliate , biology , insulin , microbiology and biotechnology , cell growth , cell , biochemistry , ecology , endocrinology , genome , gene
The presence of 10 −6 M bovine insulin in chemically defined nutrient medium prevented cell death and improved cell proliferation of the ciliate Tetrahymena pyriformis when inoculated at low initial cell density. The action of insulin was found to be restricted to the 22‐30 fragment of the B‐chain. These results suggest that small peptides are involved in regulation of cell survival and cell proliferation in Tetrahymena pyriformis.