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The influence of maternal nicotine exposure on neonatal lung alveolar epithelial status: an electron microscope study.
Author(s) -
Maritz G. S.,
Scott L.,
Thomas RA.
Publication year - 1993
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1993.1041
Subject(s) - nicotine , lung , lactation , pregnancy , physiology , andrology , medicine , pathology , biology , genetics
The aim of the present study was to investigate the effect of maternal nicotine exposure (1 mg nicotine/kg body mass/day) on neonatal lung alveolar epithelial cells. Rats (Wistar descendants) were used. The data illustrate that maternal nicotine exposure during pregnancy and lactation resulted in alveolar fenestrations, blebbing and rupturing of the blood‐air barrier. The type I pneumocyte appears to be more sensitive to the effect of nicotine than the type II pneumocytes.