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Disruption of microtubules induces formation of actin fibrils in density‐inhibited 3T3 cells.
Author(s) -
Kajstura J.,
BereiterHahn J.
Publication year - 1993
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1993.1032
Subject(s) - microtubule , microbiology and biotechnology , 3t3 cells , actin , chemistry , biophysics , fibril , biology , biochemistry , transfection , gene
In density‐inhibited 3T3 fibroblast cultures F‐actin is localized almost exclusively at the cell‐to‐cell borders. Depolymerization of microtubules results in a rearrangement of the F‐actin pattern. Numerous actin bundles are formed, most of them are anchored to the cell borders. This rearrangement is preceded by a transient rise in F‐actin content.