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The type III‐9 repeat of human fibronectin is encoded by a single exon which is not alternatively spliced.
Author(s) -
Gardella Rita,
Barlati Sergio,
Ferraboli Sergio,
Colombi Marina
Publication year - 1993
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1993.1027
Subject(s) - exon , alternative splicing , rna splicing , biology , fibronectin , genetics , homology (biology) , exon trapping , microbiology and biotechnology , gene , cell , rna
Type III homologies of human fibronectin are generally encoded by two exons, with the exception of the ED‐A and ED‐B repeats which are encoded by a single exon undergoing alternative splicing. We report that also the type III‐9 homology is encoded by a single exon. Further more, RT‐PCR analysis, performed on mRNA purified from fetal and adult tissues and from normal and tumor‐derived cell types, showed that the III‐9 region is not undergoing alternative splicing in all samples tested.