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Comparative expression of endogenous retrotransposons in adult mouse mammary gland during normal development and differentiation
Author(s) -
Asch Harold L.,
Vinci Robert Z.,
Chang Jae Y.,
Natoli Farah,
Stoler Daniel L.,
Anderson Garth R.,
Asch Bonnie B.
Publication year - 1993
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1993.1020
Subject(s) - retrotransposon , endogeny , biology , mammary gland , murine leukemia virus , mouse mammary tumor virus , carcinogenesis , endogenous retrovirus , endocrinology , medicine , microbiology and biotechnology , leukemia , virus , immunology , genetics , cancer , gene , genome , transposable element , breast cancer
Amplified expression of the endogenous retrotransposons, intracisternal A particles (IAPs) and murine leukemia virus‐related elements (MLVEs), along with decreased expression of VL30 elements frequently occurs during mouse mammary tumorigenesis. We have now analyzed the expression of these retroelements during the normal developmental and differentiation cycle of the mammary gland as found in virgin, pregnant, lactating, and post‐lactation adult female BALB/c mice. Retrotransposon expression was either unchanged or decreased during the progressive stages of the cycle compared to virgin tissue. Likewise, growth of mammary epithelial cells in primary culture had little or no effect on expression of IAPs, MLVEs and VL30 sequences. Thus, the dramatic changes involving these retrotransposons in many mouse mammary tumors appear unrelated to any normal state.