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Changes in the concentration of ions during senescence of the human erythrocyte.
Author(s) -
Cameron Ivan L.,
Hardman W. Elaine,
Smith Nancy K. R.,
Fullerton Gary D.,
Miseta Attila
Publication year - 1993
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1006/cbir.1993.1009
Subject(s) - dehydration , chemistry , senescence , ion , microanalysis , electron probe microanalysis , human blood , sulfur , red blood cell , biochemistry , biophysics , analytical chemistry (journal) , chromatography , electron microprobe , biology , mineralogy , microbiology and biotechnology , physiology , organic chemistry
Flash frozen samples of normal human blood were cryosectioned and cryodried for electron probe x‐ray microanalysis of the concentration of ions and elements in individual erythrocytes (RBCs). The data (expressed in mM/kg dry weight) demonstrated a systematic pattern of variation between the concentration of ions and elements in the RBCs. Specifically as K + and Cl decreased in concentration, Ca 2+ and sulfur increased in concentration. Phosphorous, Na + and Mg 2+ did not demonstrate a significant pattern of change. These findings are related to the dehydration and to the volume decrease that accompanies senescence of the RBC.