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Computational model of gastric motility with active‐strain electromechanics
Author(s) -
Brandstaeter Sebastian,
Gizzi Alessio,
Fuchs Sebastian L.,
Gebauer Amadeus M.,
Aydin Roland C.,
Cyron Christian J.
Publication year - 2018
Publication title -
zamm ‐ journal of applied mathematics and mechanics / zeitschrift für angewandte mathematik und mechanik
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.449
H-Index - 51
eISSN - 1521-4001
pISSN - 0044-2267
DOI - 10.1002/zamm.201800166
Subject(s) - electromechanics , motility , computational model , contractility , elasticity (physics) , biological system , neuroscience , computer science , biology , physics , simulation , medicine , cardiology , microbiology and biotechnology , thermodynamics , quantum mechanics
We present an electro‐mechanical constitutive framework for the modeling of gastric motility, including pacemaker electrophysiology and smooth muscle contractility. In this framework, we adopt a phenomenological description of the gastric tissue. Tissue electrophysiology is represented by a set of two minimal two‐variable models and tissue electromechanics by an active‐strain finite elasticity approach. We numerically investigate the implication of the spatial distribution of pacemaker cells on the entrainment and synchronization of the slow waves characterizing gastric motility in health and disease. On simple schematic model geometries, we demonstrate that the proposed computational framework is amenable to large scale in‐silico analyses of the complex gastric motility including the underlying electro‐mechanical coupling.