Premium
Cytotoxic Activities of Bis‐cyclometalated Rhodium(III) and Iridium(III) Complexes Containing 2,2’‐Biphenyldiamine
Author(s) -
Graf Marion,
Böttcher HansChristian,
MetzlerNolte Nils,
Sünkel Karlheinz,
Thavalingam Sugina,
Czerwieniec Rafał
Publication year - 2021
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.202000460
Subject(s) - iridium , monoclinic crystal system , rhodium , chemistry , dichloromethane , crystal structure , stereochemistry , methanol , heptane , single crystal , crystallography , medicinal chemistry , organic chemistry , catalysis , solvent
The synthesis and characterization of new bis‐cyclometalated complex salts [M(ptpy) 2 (2,2’‐biphenyldiamine)]PF 6 (M=Rh, 1 ; M=Ir, 2 ; ptpy=2‐( p ‐tolyl)pyridinato) are described. Compounds 1 and 2 were obtained by bridge‐splitting reactions of [{M(μ‐Cl)(ptpy) 2 } 2 ] (M=Rh or Ir) with 2,2’‐biphenyldiamine in CH 2 Cl 2 /MeOH/H 2 O mixtures. The molecular structure of compound 2 in the crystal was confirmed by single‐crystal X‐ray diffraction. 2 crystallized from dichloromethane/methanol/ n ‐heptane in the monoclinic space group P 2 1 / n . The cytotoxic activities of both new compounds were examined and evaluated. Compound 1 and 2 exhibit significant cytotoxicity against human cancer cell lines with the IC 50 values in the low micromolar range.