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Retracted: Synthesis, Crystal Structures, and Anti‐cervical Cancer Activity Evaluation of Three Trinuclear Transition Metal(II) Complexes with N,O‐Donor Schiff Base Ligand
Author(s) -
Luo TengFei,
Ji XiaoFeng,
Zhu ChengYi
Publication year - 2019
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201800522
Subject(s) - hela , schiff base , ligand (biochemistry) , chemistry , metal , transition metal , nuclear chemistry , stereochemistry , cell , catalysis , biochemistry , organic chemistry , receptor
A new bi‐nucleating Schiff base ligand, 2‐(((3‐(dimethylamino)propyl)imino)methyl)‐6‐methoxyphenol (HL 1 ) was prepared by a one‐pot condensation reaction, which was further used in the construction of three trinuclear Schiff base transition metal(II) complexes [Cu 3 (L1) 2 (OH) 2 (H 2 O) 2 ](NO 3 ) 2 ( 1 ), [Co 3 (L1) 2 (OH) 2 (H 2 O) 2 ](NO 3 ) 2 ( 2 ), and [Cu 3 (L1) 2 (N 3 ) 4 ] ( 3 ). Furthermore, a green hand grinding technique was implemented to reduce the particle size of the coordination complexes to generate the nanoscale compounds. The SEM studies reveal the formation of square and spherical particles for nano 1 and 2 , and nanorod for nano 3 . In addition, the anti‐proliferation activity of nano 1 – 3 was detected on the human cervical cancer Hela cells with CCK‐8 assay. The cell viability curves and IC 50 values indicated that only nano 1 has anti‐proliferation activity on Hela cells. To further investigate the mechanism of nano 1 induced Hela cell death, the Annexin V‐FITC/PI double staining assay, western blot assay, and ROS level detection was conducted.