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A Biocompatible Zinc(II)‐based Metal‐organic Framework for pH Responsive Drug Delivery and Anti‐Lung Cancer Activity
Author(s) -
Cai Yong,
Sheng Zhaoying,
Wang Jiying
Publication year - 2018
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201800248
Subject(s) - metal organic framework , sorption , porosity , drug delivery , zinc , nuclear chemistry , cytotoxicity , chemistry , melamine , materials science , chemical engineering , nanotechnology , in vitro , organic chemistry , biochemistry , adsorption , engineering
By using a mixed ligand approach, a new stable porous metal‐organic framework [Zn 3 (BTC) 2 (Me)(H 2 O) 2 ](MeOH) 13 ( 1 ) (H 3 BTC = 1,3,5‐benzenetricarboxylic acid, Me = melamine) was constructed by using the triangular Zn3 secondary building unit, which reveals a 3D scu ‐type topology structure with a 1D channel parallel to the c axis. The stability and porosity of 1 was confirmed via the PXRD measurement and gas sorption studies, and its size could be downsized into nanoscale (nano‐ 1 ) with the help of PVP (polyvinyl pyrrolidone). Due to its high porosity and non‐toxicity nature, this MOF was used for the 5‐Fu storage/delivery, a moderate high 5‐Fu loading capacity and pH‐dependent drug release behavior could be observed. Furthermore, the in vitro cytotoxicity of the 5‐Fu/nano‐1 composite toward the 293 cells and human lung cancer A549 cells was evaluated by MTT assay.