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A Three‐dimensional Dy III ‐based Metal‐organic Framework: Smart Drug Carrier and Anti‐lung Cancer Activity
Author(s) -
Liu FengJi,
Xu BingMei
Publication year - 2018
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201800136
Subject(s) - metal organic framework , infrared spectroscopy , elemental analysis , carboxylate , lanthanide , powder diffraction , drug delivery , nuclear chemistry , crystallography , chemistry , materials science , tricarboxylic acid , metal , drug , stereochemistry , inorganic chemistry , nanotechnology , organic chemistry , adsorption , ion , psychology , psychiatry , enzyme , citric acid cycle
A 3D lanthanide metal‐organic framework (MOF) with the formula [Dy 2 (L) 2 (H 2 O) 2 ] n ( 1 ) (H 3 L = biphenyl‐3,4′,5‐tricarboxylic acid) was synthesized under solvothermal conditions and structurally characterized by elemental analysis, powder X‐ray diffraction analysis, infrared spectroscopy, and single‐crystal X‐ray diffraction analysis. Compound 1 features a 3D porous framework based on 1D rod‐shaped Dy III ‐carboxylate chains. The efficient encapsulation and controllable release of an anticancer drug (5‐Fu) make it a promising drug delivery host. Furthermore, the GCMC simulation was used to probe the drug‐framework interaction at the atomic lever. The in vitro anti‐lung cancer activity of 1 and 5‐Fu loaded 1a were also evaluated using MTT assay.