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DNA Groove‐binding Ability of Luminescent Platinum(II) Complexes based on a Family of Tridentate N^N^C Ligands Bearing Differently Substituted Alkyl Tethers
Author(s) -
Hebenbrock Marian,
GonzálezAbradelo Darío,
Strassert Cristian A.,
Müller Jens
Publication year - 2018
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201800088
Subject(s) - chemistry , cationic polymerization , alkyl , dna , ligand (biochemistry) , luminescence , hydrogen bond , pyridine , stereochemistry , crystallography , polymer chemistry , medicinal chemistry , molecule , organic chemistry , materials science , biochemistry , receptor , optoelectronics
A family of luminescent Pt II complexes is presented capable of binding DNA duplexes via groove binding. The complexes are based on a tridentate ligand with N^N^C donor functionality bearing a triazole, a pyridine and a phenyl entity. The triazole group is used to attach a series of pendant dodecane tethers with differently charged functional head groups (neutral hydroxyl group, anionic sulfate group, cationic tetraalkylammonium group). The DNA‐binding behavior of the three resulting Pt II complexes was characterized by UV/Vis, CD, and luminescence spectroscopy as well as viscosity measurements and computational docking studies. The data clearly indicate groove binding interactions for all three complexes. In addition, a light‐switch effect was observed for the complexes upon the addition of DNA.