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Retracted: Encapsulation of 5‐Fluorouracil in a Copper(II)‐based Porous Metal‐organic Framework: Drug Delivery and Inhibiting Human Spinal Cord Tumor Cells
Author(s) -
Li Rongrui,
Liu, Shichen,
Tang Qingxi,
Wang Tianshu,
Xie Yunchuan,
Zhai Raosheng
Publication year - 2018
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201800003
Subject(s) - thermogravimetric analysis , microporous material , metal organic framework , benzoic acid , chemistry , nuclear chemistry , powder diffraction , copper , drug delivery , materials science , organic chemistry , crystallography , adsorption
Solvothermal reaction of a semirigid tricarboxylic acid with Cu(NO 3 ) 2 · 3H 2 O gives rise to a robust microporous metal‐organic framework with the formula {[Cu 2 (OH)bcb](DMF) 2 (H 2 O) 3 } n ( 1 ) [H 3 bcb = 3,5‐bis((4′‐carboxylbenzyl)‐oxy)benzoic acid, DMF = N , N ‐dimethylformamide]. Its structure was determined by single‐crystal X‐ray diffraction analysis and further characterized by elemental analysis, powder X‐ray diffraction (PXRD), and thermogravimetric (TG) analyses. The efficient encapsulation of an anticancer drug 5‐fluorouracil (5‐Fu) on the desolvated 1 ( 1a ) was studied by both grand canonical Monte Carlo (GCMC) simulation and drug release experiments. In addition, in vitro anticancer activity of compounds 1 and 5‐Fu loaded 1a were also evaluated using MTT assay.