Premium
A Water‐Soluble Mn(CO) 3 ‐Based and Non‐Toxic PhotoCORM for Administration of Carbon Monoxide Inside of Cells
Author(s) -
Mede Ralf,
Hoffmann Patrick,
Klein Moritz,
Görls Helmar,
Schmitt Michael,
Neugebauer Ute,
Gessner Guido,
Heinemann Stefan H.,
Popp Jürgen,
Westerhausen Matthias
Publication year - 2017
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201700349
Subject(s) - carbon monoxide , chemistry , corm , water soluble , carbon fibers , nuclear chemistry , inorganic chemistry , medicinal chemistry , environmental chemistry , organic chemistry , botany , materials science , biology , composite number , composite material , catalysis
The photoCORMs [Mn(CO) 3 (L)]Br with the tridentate ligands L1 = S[(CH 2 ) 2 NH 2 ] 2 ( 1 ) (CORM‐EDE3) and L2 = cyclo ‐S[(CH 2 ) 2 NH(CH 2 ‐)] 2 ( 2 ) (CORM‐EDE4) are non‐toxic and release all CO ligands upon irradiation. Reduction of the hydrophilicity of the cation by L2 (thia‐4,7‐diazacyclononane) enables accumulation of the resulting water‐soluble CORM‐EDE4 as well as administration of CO inside of cells.