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Cytotoxic and Antimicrobial Properties of Copper(II) Complexes of Pyridine and Benzimidazole Derivatives
Author(s) -
KalinowskaLis Urszula,
SzabłowskaGadomska Ilona,
Lisowska Katarzyna,
Ochocki Justyn,
Małecki Maciej,
Felczak Aleksandra
Publication year - 2017
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201700115
Subject(s) - candida albicans , staphylococcus epidermidis , benzimidazole , staphylococcus aureus , chemistry , antimicrobial , hydroxymethyl , escherichia coli , pyridine , nuclear chemistry , cytotoxic t cell , in vitro , copper , stereochemistry , microbiology and biotechnology , biochemistry , bacteria , medicinal chemistry , biology , organic chemistry , genetics , gene
The cytotoxic and antimicrobial activity of a series of six copper(II) complexes with phosphate and hydroxymethyl derivatives of pyridine and benzimidazole were investigated. The complexes and the corresponding free ligands were tested against Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, Pseudomonas aeruginosa ATCC 15442, Escherichia coli ATCC 25922, Proteus hauseri ATCC 13315, and Candida albicans ATCC 10231. Among the tested copper(II) complexes, compounds 2 and 5 containing 1 H ‐benzimidazol‐2‐ylmethyl diethyl phosphate and 2‐(hydroxymethyl)benzimidazole as ligands, respectively, were most active and limited the growth of S. aureus, E. coli , and C. albicans by 30–60 % according to concentration and microorganism. The in vitro cytotoxic activity of the Cu II complexes and free ligands towards cancerous B16 (murine melanoma) and non‐cancerous 10T1/2 (murine fibroblasts) cell lines was determined. The 10T1/2 cells were treated with the compounds at concentrations equal to IC 50 values for B16 cells. In spite of the use of relatively high concentrations of the complexes, the viability of 10T1/2 cells was very high, ca. 80 % in some cases. Stability of the Cu II complexes was evaluated in water solutions by UV/Vis spectroscopy. The copper(II) complex of 4‐(hydroxymethyl)pyridine was synthesized and identified.