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Synthesis, Characterization, and in vitro Cytotoxicity of Gold(I) Complexes of 2‐(Diphenylphosphanyl)ethylamine and Dithiocarbamates
Author(s) -
Sulaiman Adam A. A.,
Altaf Muhammad,
Isab Anvarhusein A.,
Alawad Abdullah,
Altuwaijri Saleh,
Ahmad Saeed
Publication year - 2016
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201600278
Subject(s) - ethylamine , cytotoxicity , chemistry , diphenylphosphine , a549 cell , in vitro , dichloromethane , medicinal chemistry , nuclear chemistry , stereochemistry , organic chemistry , biochemistry , solvent , phosphine , catalysis
Gold(I) complexes of 2‐(diphenylphosphanyl)ethylamine or (2‐aminoethyl)diphenylphosphine (AEP), and dithiocaarbamates ( R 2 NCS 2 ) were prepared by the reaction of these ligands with (CH 3 ) 2 S‐AuCl in dichloromethane. The synthesized complexes [Au(AEP)Cl] ( 1 ), [Au(AEP) 2 ]Cl ( 2 ), and [Au 2 ( R 2 NCS 2 ) 2 ] n ( R 2 = dimethyl ( 3 ), diethyl ( 4 ), and dibenzyl ( 5 )) were characterized by elemental analysis, IR, 1 H, 13 C and 31 P NMR spectroscopy. The complexes were evaluated for anticancer activity against three cancer cells, A549 (human lung carcinoma), HCT15 (human colon cancer), and MCF7 (human breast cancer) cell lines. Three of the five tested complexes showed significant in vitro cytotoxicity and for A549, the inhibition effect of three compounds is greater than cisplatin .