Premium
Mononuclear 1,3‐Dideazaadenine‐Ag I ‐Thyminate Base Pairs
Author(s) -
Litau Stefanie,
Müller Jens
Publication year - 2015
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201500534
Subject(s) - base pair , planarity testing , base (topology) , thymine , crystallography , base metal , chemistry , metal , stereochemistry , dna , physics , materials science , mathematics , biochemistry , mathematical analysis , organic chemistry , welding , metallurgy
When incorporating a single mispair of 1,3‐dideazaadenine (D) and thymine (T) into a regular B‐DNA duplex, a mononuclear Ag I ‐mediated D‐Ag I ‐T base pair is formed upon the addition of AgNO 3 . The nuclearity of this base pair deviates from that of the previously stablished dinuclear D‐Ag I 2 ‐T base pair. Apparently, the geometrical constraints imposed by the surrounding canonicalbase pairs do not allow the incorporation of a second Ag I , as the resulting dinuclear D‐Ag I 2 ‐T base pair would deviate significantly from planarity. This study demonstrates the importance of neighboring canonical base pairs not only on the stability but also on the identity of an artificial metal‐mediated base pair.