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Cobaltocenium Carboxylate Transition Metal Complexes: Synthesis, Structure, Reactivity, and Cytotoxicity
Author(s) -
Vanicek Stefan,
Kopacka Holger,
Wurst Klaus,
Vergeiner Stefan,
Oehninger Luciano,
Ott Ingo,
Bildstein Benno
Publication year - 2015
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201500033
Subject(s) - carboxylate , chemistry , homoleptic , transition metal , carbene , ligand (biochemistry) , reactivity (psychology) , monomer , metal , polymer chemistry , stereochemistry , medicinal chemistry , organic chemistry , catalysis , polymer , medicine , biochemistry , receptor , alternative medicine , pathology
Cobaltocenium carboxylate is an unusual betaine that functions as a formally neutral carboxylate ligand with late transition metal centers comprising Co 2+ , Ni 2+ , Cu 2+ , Ag + , Zn 2+ , Cd 2+ , Hg 2+ , and Rh + . Structurally, a rich coordination chemistry is observed – from simple monomeric homoleptic complexes to heteroleptic dimeric, trimeric, and polymeric compounds, as shown by X‐ray diffraction of 11 compounds. Chemically, thermal decarboxylation was investigated aiming at the formation of cobaltocenium‐carbene transition metal complexes, in analogy to such chemistry of imidazolium carboxylate betaines. Cytotoxicity studies of cobaltocenium carboxylate transition metal complexes were performed to evaluate the medicinal bioorganometallic potential of these compounds. While cobaltocenium carboxylate was inactive, its complexes with Ag + , Cd 2+ , and Hg 2+ triggered significant cytotoxic effects.