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Synthesis, Crystal Structure, DNA Binding, Cleavage and Docking Studies of a Novel Dinuclear Schiff‐Base Copper(II) Complex
Author(s) -
Shao Dalin,
Shi Menglu,
Zhao Qun,
Wen Jinghan,
Geng Zhirong,
Wang Zhilin
Publication year - 2015
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201400410
Subject(s) - intercalation (chemistry) , chemistry , schiff base , crystallography , copper , stereochemistry , puc19 , circular dichroism , dna , docking (animal) , crystal structure , cleavage (geology) , base pair , inorganic chemistry , materials science , biochemistry , medicine , nursing , organic chemistry , composite material , fracture (geology) , plasmid
A dinuclear copper(II) complex ( 1 ) of a Schiff‐base ligand L [2‐(( Z )‐(3‐((3‐(( Z )‐2‐hydroxybenzylideneamino)propyl)(pyridin‐4‐yl)amino)propylimino)methyl)phenol] was synthesized and characterized. Complex 1 has a [2+2] ring structure formed by two ligands and two central atoms, and each central metal atom lies in a distorted tetrahedral environment. The in vitro DNA binding studies of 1 with calf thymus‐DNA were carried out by UV/Vis, fluorescence and circular dichroism spectroscopic methods, competitive groove‐binding test, and molecular docking. Complex 1 efficiently cleaved supercoiled pUC19 DNA. As evidenced by the consistent experimental and theoretical outcomes, the copper(II) complex interacted with DNA by both partial intercalation and minor‐groove binding.