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Two Lanthanide(III) Complexes based on the Schiff Base N , N ′‐Bis(salicylidene)‐1,5‐diamino‐3‐oxapentane: Synthesis, Characterization, DNA‐binding Properties, and Antioxidation
Author(s) -
Wu Huilu,
Bai Yuchen,
Zhang Yanhui,
Pan Guolong,
Kong Jin,
Shi Furong,
Wang Xiaoli
Publication year - 2014
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201400109
Subject(s) - chemistry , schiff base , lanthanide , ligand (biochemistry) , dna , stereochemistry , hydroxyl radical , crystallography , square pyramidal molecular geometry , crystal structure , ion , antioxidant , organic chemistry , biochemistry , receptor
Abstract The Schiff base N , N ′‐bis(salicylidene)‐1,5‐diamino‐3‐oxapentane (H 2 L) and its lanthanide(III) complexes, PrL(NO 3 )(DMF)(H 2 O) ( 1 ) and Ho 2 L 2 (NO 3 ) 2 · 2H 2 O ( 2 ), were synthesized and characterized by physicochemical and spectroscopic methods. Single crystal X‐ray structure analysis revealed that complex 1 is a discrete mononuclear species. The Pr III ion is nine‐coordinate, forming a distorted capped square antiprismatic arrangement. Complex 2 is a centrosymmetric dinuclear neutral entity in which the Ho III ion is eight‐coordinate with distorted square antiprismatic arrangement. The DNA‐binding properties of H 2 L and its Ln III complexes were investigated by spectrophotometric methods and viscosity measurements. The results suggest that the ligand H 2 L and its Ln III complexes both connect to DNA in a groove binding mode; the complexes bind more strongly to DNA than the ligand. Moreover, the antioxidant activities of the Ln III complexes were in vitro determined by superoxide and hydroxyl radical scavenging methods, which indicate that complexes 1 and 2 have OH · and O 2 – · radical scavenging activity.