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Drug Release from Three‐Dimensional Cubic Mesoporous Silica Nanoparticles Controlled by Nanoimpellers
Author(s) -
Choi Eunshil,
Lu Jie,
Tamanoi Fuyuhiko,
Zink Jeffrey I.
Publication year - 2014
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201300503
Subject(s) - azobenzene , photoisomerization , mesoporous material , molecule , nanoparticle , aqueous solution , mesoporous silica , chemical engineering , fluorescence , materials science , chemistry , controlled release , nanotechnology , drug delivery , photochemistry , organic chemistry , isomerization , catalysis , optics , physics , engineering
Mesoporous silica nanoparticles with a cubic ( Ia 3 d ) pore structure are derivatized with light‐activated nanoimpellers to control the release of loaded guest molecules under external photo‐control. The nanoimpellers consist of azobenzene derivatives that are attached to the interiors of the three‐dimensional interconnected pores, and undergo photoisomerization that results in dynamic wagging motions of the unbound termini and drives the expulsion of molecules from the pores. Stimulated release experiments monitored by fluorescence spectroscopy demonstrate that the nanoimpeller‐functionalized MCM‐48 particles are able to trap and release both hydrophilic and hydrophobic cargo molecules under external photocontrol in aqueous, non‐aqueous, and intracellular environments.