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Synthesis, Characterization and Biological Evaluation of Two Silver(I) trans ‐Cinnamate Complexes as Urease Inhibitors
Author(s) -
Li Xia,
Wang Yan,
Li Yuguang,
Gou Yi,
Wang Qiang
Publication year - 2014
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201300270
Subject(s) - ligand (biochemistry) , moiety , dimer , chemistry , yield (engineering) , stereochemistry , crystallography , molecule , urease , organic chemistry , materials science , enzyme , receptor , biochemistry , metallurgy
Two new silver(I) trans ‐cinnamates, namely [Ag(2‐cca)(H 2 O)] 2 ( 1 ) and [Ag(4‐cca)] n ( 2 ) (2‐ccaH = 2‐chlorocinnamic acid and 4‐ccaH = 4‐chlorocinnamic acid), were synthesized and structurally characterized. Single crystal X‐ray studies reveal that each silver(I) atom in 1 is two‐coordinate by a 2‐chlorocinnamate ligand and one water molecule to afford a discrete centrosymmetric dimer with the ligand‐unsupported Ag···Ag interactions (3.218(4) Å), while a pair of symmetry‐related silver(I) atoms in 2 are clamped by two μ 2 ‐η 1 :η 1 4‐chlorocinnamate ligands to yield a binuclear silver(I) moiety incorporating a ligand‐supported Ag···Ag interaction (2.819(5) Å). Both complexes 1 and 2 show potent urease inhibitory activities with the respective IC 50 values of 0.66 and 1.10 μM.