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Osmium‐Nitrosyl Complexes with Glycine, Picolinic Acid, L ‐Proline and D ‐Proline: Synthesis, Structures and Antiproliferative Activity
Author(s) -
Gavriluta Anatolie,
Novak Maria,
Tommasino Jean Bernard,
Meier Samuel M.,
Jakupec Michael A.,
Luneau Dominique,
Arion Vladimir B.
Publication year - 2013
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201300054
Subject(s) - proline , picolinic acid , glycine , chemistry , aqueous solution , stereochemistry , electrochemistry , amino acid , medicinal chemistry , biochemistry , organic chemistry , electrode
The reactions of [Os(NO)Cl 5 ] 2– with glycine (GlyH), picolinic acid (PicoH), L ‐proline ( L ‐ProH) and D ‐proline ( D ‐ProH) afforded four novel complexes of the general formula [Os(NO)Cl 3 (AA)] – , where AA = Gly, Pico, L ‐Pro and D ‐Pro, respectively. X‐ray diffraction studies have revealed that in all cases the same isomer type from three theoretically possible, has been isolated, namely mer (Cl), trans (NO, O)‐[Os(NO)Cl 3 (AA)] – . Spectroscopic and electrochemical properties, behavior in aqueous solution and antiproliferative activity in three human cancer cell lines are also reported.