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Metal‐binding Sites of N ‐Acetylneuraminic Acid
Author(s) -
Illi Sarah,
Schulten Johanna,
Klüfers Peter
Publication year - 2013
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201200415
Subject(s) - neuraminic acid , steric effects , chemistry , sialic acid , palladium , n acetylneuraminic acid , metal , stereochemistry , residue (chemistry) , metal ions in aqueous solution , derivative (finance) , medicinal chemistry , organic chemistry , catalysis , biochemistry , financial economics , economics
Sialic acid represents a group of thirty derivates of neuraminic acid with various substituents at the amino residue and the alcoholic hydroxy groups. We analysed the behaviour of the tetracoordinated metal ions palladium(II) and silicon(IV) against the most important derivative N ‐acetylneuraminic acid (NANA). The molecular structures were assigned by a combined 1 H, 13 C and 29 Si NMR‐spectroscopic approach. Despite the presence of many different functional groups, the coordination chemistry of NANA with Pd II follows established rules. Coordination via the N ‐acetyl‐group – sterically impossible with Pd II – was realised with Si IV .