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Comparative Study of three Mononuclear Vanadium‐Aromatic 1, 2‐Diol Complexes: Structure, Characterization and Anti‐Proliferating Effects Against Cancer Cells
Author(s) -
Chi Zixiang,
Zhu Linli,
Lu Xiaoming,
Yu Hongtao,
Liu Bing
Publication year - 2012
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201200097
Subject(s) - chemistry , vanadium , stereochemistry , crystallography , redox , catechol , crystal structure , hydrogen bond , diol , molecule , polymer chemistry , inorganic chemistry , organic chemistry
Three mononuclear vanadium complexes containing aromatic 1, 2‐diols (catechol and naphthalene‐2, 3‐diol) ligands,[V IV O(cat) 2 ][1, 3‐HPDA] 2 · CH 3 OH ( 1 ), [V IV O(N‐2, 3‐D) 2 ][1, 3‐H 2 PDA] ( 2 ), and [V V O 2 (N‐2, 3‐D)(1, 3‐HPDA)] · 1, 3‐PDA ( 3 ) (cat = catechol, N‐2, 3‐D = naphthalene‐2, 3‐diol, 1, 3‐PDA = 1, 3‐propanediamine) were synthesized and characterized by X‐ray diffraction, IR and UV/Vis spectroscopy, and cyclovoltammetry. X‐ray analysis reveals that the spatial frameworks of complexes 1 – 3 are all constructed by hydrogen bonds donated by [1, 3‐H n PDA] n + ( n = 1, 2) cation, forming distinct chain structures. Complexes 1 and 2 are both in the non‐chiral form of VO(L) 2 , but 2 crystallizes in the chiral space group ( P 6 5 22), due to the symmetry element of spiral axis, whereas complex 3 contains both enantiomers of chiral VO 2 (L 1 )(L 2 ) units, but crystallizes in the non‐chiral space group ( P $\bar{1}$ ). The electrochemical behavior of the three complexes is studied in comparison with that of the free ligands. Complex 1 shows a pair of potentials assigned to the redox behavior of vanadium, while complexes 2 and 3 exhibit no such redox potentials. Pharmaceutical screening of complexes 1 – 3 were carried out against three representative cancer cell lines: A‐549 (lung cancer), Bel‐7402 (liver cancer) and HCT (colonic cancer) by MTT [3‐(4, 5‐dimethylthiazoyl‐2‐yl)‐2, 5‐diphenyltetrazolium bromide] assay. The results show that the vanadium‐catechol complex 1 exhibits more obvious anti‐proliferating effects against the three cell‐lines, whereas the two vanadium‐N‐2, 3‐D complexes 2 and 3 basically display no such effects.