Premium
Synthesis and Characterization of Magnetic Composites: Intercalation of Naproxen into Mg‐Al Layered Double Hydroxides Coated on Fe 3 O 4
Author(s) -
Rezvani Zolfaghar,
Sarkarat Maryam
Publication year - 2012
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201100487
Subject(s) - thermogravimetric analysis , coprecipitation , intercalation (chemistry) , layered double hydroxides , materials science , hydroxide , naproxen , thermal stability , phase (matter) , powder diffraction , chemical engineering , nuclear chemistry , chemistry , inorganic chemistry , crystallography , organic chemistry , medicine , alternative medicine , pathology , engineering
In this work the synthesis and characterization of a magnetic composite is described. It was prepared by deposition of Nap‐Mg‐Al‐LDH on Fe 3 O 4 by a coprecipitation method. The structures of the obtained products were studied by powder X‐ray diffraction, FT‐IR spectroscopy, elemental analysis, and thermogravimetric analysis. From the X‐ray diffraction results, it was found that Fe 3 O 4 was successfully distributed into the layered double hydroxide (LDH) phase. Furthermore, the increase in the basal spacing of LDHs from 0.881 nm to 2.157 nm shows that naproxen was successfully intercalated into the interlayer space. The particle size was estimated using transmission electron microscopy. Thermogravimetric studies indicate that the thermal stability of naproxen was enhanced after intercalation. Moreover, in vitro drug release experiments in phosphate buffer solution (pH = 7.4) were investigated.