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Synthesis, Characterization, DNA Binding Properties, and Antioxidant Activity of Novel Copper(II) and Zinc(II) Complexes with Bis(pyrrol‐2‐yl‐methylamine) Ligands
Author(s) -
Li Yong,
Yang ZhengYin,
Wang Yuan
Publication year - 2011
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201000199
Subject(s) - chemistry , molar conductivity , ethidium bromide , copper , zinc , antioxidant , proton nmr , bromide , nuclear chemistry , dna , medicinal chemistry , stereochemistry , inorganic chemistry , polymer chemistry , photochemistry , organic chemistry , elemental analysis , biochemistry
Abstract Three novel ligands H 4 L n ( n = 1–3) and their copper(II) and zinc(II) complexes were prepared and characterized on the basis of elemental analyses, molar conductivity, 1 H NMR, UV/Vis, and IR spectroscopy as well as mass spectrometry. DNA binding properties of the ligands and their complexes were investigated by absorption spectroscopy, ethidium bromide displacement experiments, and viscosity measurements. The experimental results indicate that the new ligands and their complexes can bind to DNA and the binding affinities of the complexes are higher than those of the ligands. In addition, the antioxidant activity of the ligands and complexes was determined by superoxide and hydroxyl radical scavenging methods in vitro, indicating that the complexes exhibit more effective antioxidant activity than the ligands alone.