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Experimental and Theoretical Approaches to the Protonation of Thiourea: A Convenient Nucleophile in Coordination Chemistry Revisited
Author(s) -
Schiessl Wolfgang C.,
Summa Nadine K.,
Weber Christian F.,
Gubo Sonja,
DückerBenfer Carlos,
Puchta Ralph,
van Eikema Hommes Nico J. R.,
van Eldik Rudi
Publication year - 2005
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.200500157
Subject(s) - protonation , thiourea , chemistry , potentiometric titration , aqueous solution , acid dissociation constant , nucleophile , inorganic chemistry , dissociation (chemistry) , computational chemistry , medicinal chemistry , organic chemistry , ion , catalysis
The protonation of thiourea was reinvestigated in aqueous and non‐aqueous media using potentiometric, UV‐vis, NMR, MS spectroscopy, as well as DFT calculations. In aqueous medium, no evidence for protonation could be found in the pH range 0 to 7, in agreement with typical pK a values (acid dissociation constants of protonated thiourea) quoted in the literature of around ‐1.2. Most of the protonation constants quoted in the literature are incorrect and apparently refer to pK a values. Protonation of thiourea occurs at a much higher pK a value in methanol and in water‐dioxane mixtures, which must be related to the stabilization of the protonated species in such media.