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Dinuclear and Mononuclear Platinum(II) and Palladium(II) Complexes with Modified 2,2′‐Dipyridylamine Ligands Featuring a Cisplatin Analogous Structure Motif
Author(s) -
Fakih Sarah,
Tung Wing Chau,
Eierhoff Dirk,
Mock Christian,
Krebs Bernt
Publication year - 2005
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.200500011
Subject(s) - chemistry , triclinic crystal system , platinum , orthorhombic crystal system , palladium , cisplatin , crystallography , stereochemistry , ligand (biochemistry) , linker , crystal structure , organic chemistry , chemotherapy , medicine , biochemistry , receptor , surgery , operating system , computer science , catalysis
In modern cancer therapy the clinical application of platinum‐based drugs is more and more limited by the occurrence of intrinsic or acquired resistances. In this context the potential use of dinuclear platinum complexes in chemotherapy is increasingly relevant. The novel complexes Pd(Bzdpa)Cl 2 , Pd 2 (C 4 H 8 (dpa) 2 )Cl 4 , and Pt 2 (C 4 H 8 (dpa) 2 )Cl 4 allow a direct comparison of mono‐ and dinuclear palladium and platinum complexes respectively deriving from a 2,2′‐dipyridylamine (Hdpa) ligand system. They were characterized by single crystal X‐ray analysis as well as infrared spectroscopy and elemental analysis. The cisplatin analogous mononuclear palladium complex Pd(Bzdpa)Cl 2 ( 1 ) (Bzdpa: (2,2′‐dipyridylbenzyl)amine) belongs to a range of 2,2′‐dipyridylamine‐based compounds which were extensively studied in our laboratories. 1 crystallizes in the orthorhombic space group Pna 2 1 with a = 13.722(3), b = 13.457(3), c = 9.483(2), V = 1751.1(6) Å 3 , and Z = 4. The metal binding motif of 1 was expanded by a flexible butyl‐linker to form the tetradentate C 4 H 8 (dpa) 2 ligand. The resulting isotypic dinuclear complexes Pd 2 (C 4 H 8 (dpa) 2 )Cl 4 ·2CH 3 CN ( 2 ) and Pt 2 (C 4 H 8 (dpa) 2 )Cl 4 ·2CH 3 CN ( 3 ) crystallize in the triclinic space group $P{\bar 1}$ with a = 7.8427(2), b = 8.7940(2), c = 11.7645 (3), α = 79.219(2)°, β = 84.033(2)°, γ = 87.744(2)°, V = 792.58(3) Å 3 ( 2 ) and a = 7.831(5), b = 8.814(5), c = 11.817(5), α = 79.271(5)°, β = 83.571(5)°, γ = 88.063(5)°, V = 796.3(8) Å 3 ( 3 ), both with one centrosymmetrical molecule in the unit cell.