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Reaction of Hydroxyurea with Iron(III): Products and the Stoichiometry of the Redox Reaction
Author(s) -
Kujundžić Nikola,
Nigović Biljana,
Sanković Krešimir
Publication year - 2004
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.200400283
Subject(s) - ribonucleotide reductase , stoichiometry , chemistry , mole , redox , hydrogen peroxide , aqueous solution , horseradish peroxidase , peroxidase , inorganic chemistry , reaction mechanism , nuclear chemistry , medicinal chemistry , enzyme , organic chemistry , biochemistry , catalysis , protein subunit , gene
Products and reaction stoichiometry of the interaction between iron(III) and hydroxyurea (HU) in aqueous solutions were studied. Under condition of an excess of iron(III) over hydroxyurea, initially formed mono(hydroxyureato)iron(III) complex decomposed through redox processes, forming two moles of Fe II , one mole of NH 4 + , one mole of CO 2 , and 0.5 mole of N 2 O per 1 mole of initially present HU. Hydroxyurea radical, H 2 N‐CO‐NHO ? , was detected in the course of the reaction. The possible mechanism of the formation of the products is discussed and compared with that obtained for horseradish peroxidase mediated oxidation of hydroxyurea with hydrogen peroxide. The possibility of direct reaction of hydroxyurea with the iron center of protein R2 of the ribonucleotide reductase is proposed. The reaction examined may serve as a simple model for testing the suggested hydroxyurea like activity for chemical substances.