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Asymmetric Catalysis. 151 [1] Wilkinson‐type [Rh(diop)(PPh 3 )Hal] Catalysts in the Enantioselective Hydrogenation of Ketopantolactone
Author(s) -
Brunner Henri,
Zettler Christian,
Zabel Manfred
Publication year - 2003
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.200300009
Subject(s) - enantioselective synthesis , diastereomer , crystal structure , catalysis , rhodium , chemistry , stereochemistry , medicinal chemistry , organic chemistry
The Wilkinson‐type catalysts [Rh(diop)(PPh 3 )Cl] and [Rh(diop)(PPh 3 )I] have been synthesised and characterised by X‐ray structure analysis. In the crystal the distorted square planar compounds form pairs of diastereomers. The compounds were tested as catalysts in the enantioselective hydrogenation of ketopantolactone. With 65 % ee the iodo complex achieved a higher enantioselectivity than the chloro complex (55 % ee).