Open AccessGastric precancerous conditions in patients with chronic dyspepsia
Author(s) -
Win ThetMar,
Aye KhinSan,
Aye ThanThan
Publication year - 2021
Publication title -
gastrohep
Language(s) - English
Resource type - Journals
ISSN - 1478-1239
DOI - 10.1002/ygh2.483
Subject(s) - rapid urease test , intestinal metaplasia , medicine , gastroenterology , atrophic gastritis , incidence (geometry) , helicobacter pylori , cancer , gastritis , endoscopy , chronic gastritis , physics , optics
Abstract Introduction Gastric cancer (GC) is one of the most lethal malignancies worldwide, though a decrease in incidence. Helicobacter pylori is positively associated with gastric precancerous conditions. Detection of these conditions, namely atrophic gastritis (AG) and intestinal metaplasia (IM), and their association with H pylori infection is important for further detection and reduction of overall cancer incidence. Aim To detect the prevalence of H pylori infection and gastric precancerous conditions in patients with chronic dyspepsia by High Definition White Light Endoscopy (HD‐WLE) and Narrow Band Imaging with Magnifying Endoscopy (NBI‐ME). Methods This was a hospital‐based descriptive study including chronic dyspeptic patients aged over 50 years. H pylori infection was diagnosed by a rapid urease test. AG and IM were detected by endoscopy (HD‐WLE and NBI‐ME) and confirmed by histology. Detection rates of each method were compared. Results Totally 143 patients (55 males/88 females) with a mean age of 64.57 ± 9.957 years were included. H pylori infection rate was 53.84% (n = 77). Twenty‐two patients with AG (44.9% of patients with atrophy) and 37.84% (14/37) of patients with IM have H pylori infection. There was a statistically significant difference in detection rates between HD‐WLE and NBI‐ME for IM ( P =0.001) but not for AG ( P =0.250). Conclusion H pylori infection is still high in Myanmar. There were significant associations between H pylori and gastric precancerous lesions. Detection of atrophic gastritis and intestinal metaplasia by routine usage of NBI‐ME along with test and treat H pylori infection are the strategies to reduce the incidence of gastric cancer.