Proteins interacting with Lin1p, a putative link between chromosome segregation, mRNA splicing and DNA replication in  Saccharomyces cerevisiae | Zendy

Bialkowska Agnieszka | Zendy; Kurlandzka Anna | Zendy

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Proteins interacting with Lin1p, a putative link between chromosome segregation, mRNA splicing and DNA replication in Saccharomyces cerevisiae

Author(s) -

Bialkowska Agnieszka,

Kurlandzka Anna

Publication year - 2002

Publication title -

yeast

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.923

H-Index - 102

eISSN - 1097-0061

pISSN - 0749-503X

DOI - 10.1002/yea.919

Subject(s) - biology , establishment of sister chromatid cohesion , genetics , cohesin , rna splicing , chromosome segregation , dna replication , saccharomyces cerevisiae , premature chromosome condensation , control of chromosome duplication , mitosis , chromosome , dna , microbiology and biotechnology , gene , rna

Proteins involved in chromosome segregation during mitosis are likely to participate in other cell cycle‐coordinated processes. Using a two‐hybrid screen we identified a novel nuclear protein, Lin1, interacting with Irr1p/Scc3p, a component of the cohesin complex. The second round of two‐hybrid assay with Lin1p as the bait resulted in the identification of six proteins: Prp8, Slx5, Siz2, Wss1, Rfc1 and YIL149w. These proteins have previously been shown to participate in mRNA splicing, DNA replication, chromosome condensation, chromatid separation and alternative cohesion. We propose that Lin1p may constitute a link among these processes. Copyright © 2002 John Wiley & Sons, Ltd.

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