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Metabolism of phospholipids in the yeast Schizosaccharomyces pombe
Author(s) -
Holič Roman,
Pokorná Lucia,
Griač Peter
Publication year - 2020
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/yea.3451
Subject(s) - schizosaccharomyces pombe , yeast , biology , schizosaccharomyces , phospholipid , membrane , biochemistry , model organism , eukaryotic cell , organism , microbiology and biotechnology , cell , saccharomyces cerevisiae , genetics , gene
The fission yeast Schizosaccharomyces pombe is an important model organism for the study of fundamental questions in eukaryotic cell and molecular biology. A plethora of cellular processes are membrane associated and/or dependent on the proper functioning of cellular membranes. Phospholipids are not only the basic building blocks of cellular membranes; they also serve as precursors to numerous signaling molecules. In this review, we describe the biosynthetic pathways leading to major S. pombe phospholipids, how these pathways are regulated, and what is known about degradation and turnover of fission yeast phospholipids. This review also addresses the synthesis, regulation and the role of water‐soluble phospholipid precursors. The last chapter of the review is devoted to the use of S. pombe for the biotechnological production of value‐added lipid molecules.