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Monovalent cation transporters at the plasma membrane in yeasts
Author(s) -
Ariño Joaquín,
Ramos José,
Sychrova Hana
Publication year - 2019
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/yea.3355
Subject(s) - transporter , intracellular , efflux , vacuole , biology , yeast , saccharomyces cerevisiae , potassium , antiporter , membrane , homeostasis , atpase , sodium , biochemistry , microbiology and biotechnology , function (biology) , membrane transport , biophysics , ion transporter , enzyme , chemistry , gene , organic chemistry , cytoplasm
Maintenance of proper intracellular concentrations of monovalent cations, mainly sodium and potassium, is a requirement for survival of any cell. In the budding yeast Saccharomyces cerevisiae , monovalent cation homeostasis is determined by the active extrusion of protons through the Pma1 H + ‐ATPase (reviewed in another chapter of this issue), the influx and efflux of these cations through the plasma membrane transporters (reviewed in this chapter), and the sequestration of toxic cations into the vacuoles. Here, we will describe the structure, function, and regulation of the plasma membrane transporters Trk1, Trk2, Tok1, Nha1, and Ena1, which play a key role in maintaining physiological intracellular concentrations of Na + , K + , and H + , both under normal growth conditions and in response to stress.