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The Saccharomyces cerevisiae poly (A) binding protein (Pab1): Master regulator of mRNA metabolism and cell physiology
Author(s) -
Brambilla Marco,
Martani Francesca,
Bertacchi Stefano,
Vitangeli Ilaria,
Branduardi Paola
Publication year - 2019
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/yea.3347
Subject(s) - saccharomyces cerevisiae , poly(a) binding protein , stress granule , biology , messenger rna , p bodies , rna binding protein , microbiology and biotechnology , translation (biology) , yeast , rna , biochemistry , gene
Pab1, the major poly (A) binding protein of the yeast Saccharomyces cerevisiae , is involved in many intracellular functions associated with mRNA metabolism, such as mRNA nuclear export, deadenylation, translation initiation and termination. Pab1 consists of four RNA recognition motifs (RRM), a proline‐rich domain (P) and a carboxy‐terminal (C) domain. Due to its modular structure, Pab1 can simultaneously interact with poly (A) tails and different proteins that regulate mRNA turnover and translation. Furthermore, Pab1 also influences cell physiology under stressful conditions by affecting the formation of quinary assemblies and stress granules, as well as by stabilizing specific mRNAs to allow translation re‐initiation after stress. The main goal of this review is to correlate the structural complexity of this protein with the multiplicity of its functions.